1. Ask a clear clinical question
2. Acquire best available evidence
3. Appraise evidence for quality
4. Apply evidence to practice
5. Assess the outcomes
Therapy/Intervention
Systematic Reviews or Meta-Analysis
Randomized Controlled Trials
Clinical Practice Guidelines
Nonrandomized Controlled Trials
Cohort Study or Case-Control Studies
Meta-Synthesis of Qualitative or Descriptive Studies
Qualitative or Descriptive Studies
Expert Opinion
Diagnosis, Prognosis/Prediction
Synthesis of Cohort Study or Case-Control Studies
Single Cohort Study or Case-Control Studies
Meta-Synthesis of Qualitative or Descriptive Studies
Single Qualitative or Descriptive Studies
Expert Opinion
Meaning
Meta-synthesis of Qualitative Studies
Cohort Studies
Single Qualitative studies
Synthesis of Descriptive Studies
Single Descriptive Studies
Expert Opinion
Prevention
Randomized Controlled Trials
Cohort Studies
Case Control
Case Series
Economic Analysis
Economic Analysis
Identify alternative and keywords to describe each PICO component.
This allows the database to search for relevant articles that may have been indexed using one other alternative words. These words and terms can (and should) come from many sources, including everyday language and database thesauri.
Consider the following questions to uncover alternative and keywords for each component:
Population
Who is the patient? What is the population or disorder of interest? What are key characteristics of the patient, problem or population? What health concerns are of interest?
Intervention
What is the intervention or event? What therapeutic, diagnostic, preventative or other health care actions or processes of interest? What do you want to do for the patient or population?
Comparison (if applicable)
Is there an alternative intervention? What is the intervention being compared to?
Outcome
What is the effect of the treatment/intervention? What are the results of the intervention? What are you trying to accomplish, improve, or effect?
Tip: Consult the MeSH thesaurus at http://www.ncbi.nlm.nih.gov/mesh.
MeSH (Medical Subject Headings) is the controlled vocabulary thesaurus that indexers at the U.S. National Library of Medicine use to classify articles in PubMed. MeSH terms are also used by many other nursing and health research databases
MeSH Tutorial - https://www.nlm.nih.gov/bsd/disted/meshtutorial/introduction/index.html
Tip: Keep a record of the words used in your search.